6 Best Mushrooms for Gut Health (Backed by Science)

Key Takeaways :

Gut health might not seem important, but it affects everything from your mental state and skin health to your digestion and immune system.
Functional mushrooms like lion’s mane, reishi, chaga, turkey tail, shiitake, and maitake can all help support the gut in different ways.
Not all mushroom supplements are created equal. Look for supplements made with dual-extracted, 100% mushroom fruiting bodies that are grown on wood.
Mushrooms can be great for gut health, but they really work best alongside a solid diet, regular exercise, and a good night’s sleep.

Mushrooms are one of those things people either love or hate, but they’re so much more than a controversial pizza topping. Medicinal mushrooms are fungi that can pack some serious health benefits. In fact, they usually don’t even look like the button mushrooms you’re used to seeing in the grocery store.

Functional mushrooms can have many uses, from supporting brain power to promoting gut health. But why is gut health so important, and which mushrooms are best for the gut? Here’s the lowdown on everything you need to know.

What Is Gut Health?

The “gut” is a simple term that basically includes the entire digestive tract. Specifically, when people talk about their “guts,” they usually mean their stomachs and intestines.

These organs are part of every human body, so it might seem strange to think that they can be healthy or unhealthy. In fact, there are a few key factors that make up gut health.

These include:

The Gut Microbiome : There are trillions of bacteria that live throughout your intestines, but mostly in your large intestine. These bacteria produce digestive enzymes and other compounds that are important for health. That said, this delicate balance is easily upset.
Gut Motility : This refers to how long it takes the body to digest food. If food moves slowly through the digestive tract, it can cause indigestion. Normally, it should take between two to five days to digest food.
Intestinal Permeability : The intestinal walls naturally allow nutrients to pass through them into the bloodstream. However, they can sometimes be a little too open, allowing toxins to pass through as well.
Irritation : The gut can get irritated by bacteria, viruses, toxins, and even the food you eat.

Why Is Gut Health Important?

You might not spend a lot of time thinking about what goes on inside your digestive system, but we can pretty much guarantee you’ll notice when something’s off. It could start with indigestion, bloating, nausea, or constipation. However, the gut deals with far more than just digestion.

The gut is the physical center of the body, both in location and function. Having poor gut health means you won’t be able to absorb as many nutrients from your food, you might experience gut irritation, and you might even feel stressed.

There’s something called the gut-brain axis, which basically explains how gut health affects emotional and brain health, and vice versa. For instance, the gut creates 95 percent of the body’s serotonin. This chemical doesn’t just play a role in mood and digestion — it’s also an ingredient in melatonin, the body’s sleep hormone.

The gut also affects immune health, and having poor gut health can leave you more open to catching colds. There’s even something called the gut-skin axis, which describes how gut health can affect skin health. It turns out that poor gut health could be behind your breakouts, dryness, or overall lackluster skin tone.

How Mushrooms Support Gut Health

Mushrooms are one of those foods that just look like they’ll be healthy. That being said, it always helps to know how those foods work.

One key feature in mushrooms is prebiotic fiber, especially beta-glucans, which act as food for beneficial gut bacteria. By nourishing these microbes, mushrooms help maintain balance and diversity in gut flora (this is a good thing, trust us).

Beyond that, mushrooms can play a role in immune modulation, affecting gut-associated lymphoid tissue (GALT), which can help defend the intestinal lining. They also contribute to barrier support by strengthening tight junctions, the cellular “seals” that help prevent leaky gut.

Finally, many mushrooms can have anti-inflammatory effects that soothe irritation in the gastrointestinal tract. This can help reduce discomfort and support long-term digestive health.

6 Best Mushrooms for Gut Health

Clearly, the gut is the star of the show when it comes to health. Fix your gut, and you might just fix a host of other issues along with it!

There are plenty of ways you can support your gut health, such as exercising, getting sunlight, managing stress, getting plenty of sleep, and eating gut-healthy foods. However, another major thing you can do is consider taking mushroom supplements. Here are our favorites for gut health.

Name	Key Benefit	Typical Dose
Lion’s Mane	Supports the gut-brain axis and microbiome diversity	500 to 1000 mg
Reishi	Immune modulation and anti-inflammatory properties	1000 to 1500 mg
Chaga	Antioxidant-rich and provides gut barrier support	500 to 1000 mg
Turkey Tail	Enhances beneficial gut bacteria growth	1000 to 3000 mg
Shiitake	Supports gut microbiota and immune health	500 to 1000 mg
Maitake	Stimulates SCFA production and gut balance	1000 to 2000 mg

1. Lion’s Mane

Lion’s mane (Hericium erinaceus) is well-known for its neuroprotective properties, but its benefits extend to gut health, thanks to the intricate connection between the brain and the gastrointestinal system.

Lion’s mane can support the body’s production of NGF, a protein essential for the growth and maintenance of neurons. This includes the enteric nervous system, often referred to as the "second brain," which helps control gut function.

Lion’s mane mushroom is also a rich source of beta-glucans. These are carbohydrates that double as prebiotic fiber, which acts like food for the bacteria in your small and large intestines.

Lion’s mane can also bind to toxins, encouraging the body’s natural detoxification pathways.

This can ease irritation in the gut and help support the gut-brain connection. This leads to some other benefits of lion’s mane, such as supporting brain health, focus, and mental health.

Human/Animal Study Snapshot:

In a pilot study, short-term H. erinaceus intake in healthy adults was associated with shifts in gut microbiota composition.
In ulcerative colitis model mice, H. erinaceus polysaccharides lowered inflammation and reshaped the microbiota.

Recommended Extract Dose: Common retail servings for hot-water extracts are 500 to 1,500 mg/day, which aligns with doses used across cognition and general wellness studies. Gut-specific human dosing is not yet standardized.

2. Reishi

Reishi mushrooms can support the intestinal lining, encouraging healthy intestinal permeability. Reishi can also support a balanced gut microbiome, specifically when it comes to the balance between bacteria and yeast.

Reishi (Ganoderma lucidum), often dubbed the "mushroom of immortality," has been used in traditional medicines for hundreds of years. This mushroom has many benefits, especially when it comes to gut health.

Reishi contains polysaccharides and triterpenoids that may support the integrity of the intestinal lining. By supporting a strong gut lining, Reishi could help keep harmful substances from escaping the gut into the bloodstream.

Reishi also has antimicrobial properties that may stop or slow the growth of Candida albicans, a common yeast that can overpopulate the gut and cause some less-than-pleasant side effects. These can include brain fog, indigestion, sugar cravings, and more.

Human/Animal Study Snapshot:

In a landmark mouse study, G. lucidum extracts reduced weight gain and improved metabolic markers by modulating gut microbiota.

Recommended Extract Dose: Based on research, you may want to look for a reishi extract that contains 1,000 to 3,000 mg/day, often with split doses. Standardization to polysaccharides or triterpenes varies by brand.

3. Chaga

Chaga (Inonotus obliquus) is a fungus that thrives on birch trees. Chaga is also a great source of antioxidants, which are molecules that can help neutralize the effects of free radicals. The gut lining is especially susceptible to damage from oxidative stress, which can cause it to not work as well.

Chaga mushroom alsois another mushroom that contains lots of beta-glucans. Beyond its prebiotic properties, chaga can also support balance within the gut microbiome and support the immune system. Both chaga and lion’s mane contain certain compounds that can help soothe irritation within the gut, along with classic symptoms of conditions like irritable bowel syndrome, Crohn's disease, and ulcerative colitis. , as well.

These can help support gut health and also overall health in both the short term and long term.

Human/Animal Study Snapshot:

In animal models, I. obliquus polysaccharides modulated gut microbial diversity and showed anti-inflammatory effects relevant to GI conditions.
Mouse work in pancreatitis and metabolic contexts also reports microbiota shifts linked to functional outcomes.

Recommended Extract Dose: Given limited human gut data, a conservative range is 500 to 1,500 mg/day of hot-water extract, but you may want to avoid long-term high doses. Talk to a doctor if you take anticoagulants or hypoglycemics.

4. Turkey Tail

Turkey tail (Trametes versicolor) is packed with polysaccharopeptides, especially PSK (polysaccharide-K) and PSP (polysaccharopeptide). These unique compounds have drawn the attention of researchers for their potential prebiotic effects. They can feed the good gut bacteria like Bifidobacteria and Lactobacillus, supporting a healthier and more diverse microbiome.

Beyond its prebiotic properties, turkey tail can also help clear the gut of unwanted bacteria. Studies have shown that extracts from turkey tail can slow or stop the growth of harmful bacteria such as Staphylococcus aureus, Escherichia coli, and Listeria monocytogenes, as well as the fungus Candida albicans.

Human/Animal Study Snapshot:

In a randomized, placebo-controlled human study, the turkey tail polysaccharopeptide PSP noticeably modulated gut microbiota in healthy adults.

Recommended Extract Dose:

Products standardized to PSP/PSK commonly provide 1 to 3 g/day of hot-water extract (often in divided doses).

5. Shiitake

Shiitake mushrooms (Lentinula edodes) aren’t just a stir-fry staple — they’ve got serious gut-supporting potential, too. Like the other mushrooms on our list, these mushrooms contain beta-glucans, a class of polysaccharides that may act as prebiotics.

These complex carbs aren't digested by our systems, but instead pass through to feed the bacteria in the gut. The result is an increase in short-chain fatty acids (SCFAs) like butyrate, which can improve intestinal barrier function and the body’s response to inflammation.

Shiitake mushrooms are also rich in bioactive compounds that may support gut health by changing the immune system. Regularly eating shiitake has been linked to increased levels of secretory immunoglobulin A (sIgA), an antibody that helps promote immunity in the gastrointestinal tract.

Higher sIgA levels can strengthen the gut's defense against bad bacteria and viruses. Additionally, shiitake intake has been associated with reduced levels of C-reactive protein (CRP), a marker of systemic inflammation.

Human/Animal Study Snapshot:

In a randomized, double-blind human trial, a shiitake beta-glucan-enriched mixture ( for 8 weeks modulated colonic microbiota versus placebo.

Recommended Extract Dose: For beta-glucan-enriched extracts, a practical translation is about 2 to 4 g/day of beta-glucans.

6. Maitake

Maitake mushrooms (Grifola frondosa) contribute to gut health by promoting the production of short-chain fatty acids (SCFAs), such as butyrate, acetate, and propionate. To get more technical, these compounds are produced when beneficial gut bacteria ferment the fibers and polysaccharides found in maitake.

SCFAs play an important role in maintaining intestinal health by providing energy for colon cells, strengthening the gut barrier, and reducing inflammation. They also help regulate the gut’s pH, which makes it harder for bad bacteria to thrive.

Human/Animal Study Snapshot:

In a mouse study, maitake powder shifted the gut microbiota toward SCFA-producing bacteria (such as Lachnospiraceae) after 8 weeks.
Recent analyses of purified maitake polysaccharides show selective effects on human gut microbes in vitro, supporting prebiotic potential.

Recommended Extract Dose (typical supplement serving):

For hot-water extracts, 1,000 to 2,000 mg/day (or labeled equivalent in drops/mL) is a practical dosage.

How Can You Take Mushrooms for Gut Health?

When you’re looking for a mushroom supplement, don’t fall victim to clever marketing. There are three key things you need to be aware of:

How the Mushroom Is Processed : The human body cannot use the beneficial compounds in raw mushrooms unless they’re extracted, so make sure you specifically look for supplements that use mushroom extract.
How the Mushroom Is Fed : Some brands feed their mushrooms grains instead of wood to help speed up production. However, this can lead to a lower-quality supplement that might not have all of the benefits you’re looking for.
Which Part of the Mushroom Is Used : Mycelium, or the underground part of the mushroom, is commonly used in supplements. However, it’s also not as high in beta-glucans and other beneficial compounds. Instead, you may want to look for supplements that use mushroom fruiting bodies.

Our Mushroom Coffee+ checks all of these boxes and more. Featuring double-extracted, wood-fed lion’s mane and chaga fruiting bodies, our formula is made with your gut in mind. Plus, it contains other ingredients that can help support gut health. For instance, collagen can help support the intestinal lining, while L-theanine can help ease feelings of stress.

Safety, Interactions & Contraindications

While mushrooms are generally safe, it’s important to consider potential risks. For individuals with autoimmune conditions, immunomodulatory mushrooms like reishi may kick immune activity into overdrive, contributing to flare-ups.

Some people also experience allergic reactions to fungi, so monitoring for sensitivities is key. In addition, mushrooms can interact with certain medications. For example, compounds in some species may influence anticoagulant drugs by affecting clotting, or immunosuppressants by altering immune function.

Even natural compounds can create unintended effects, so it’s wise to talk to a healthcare provider before adding mushroom supplements to your routine. This is especially true if you have existing health conditions or are taking prescription medications.

How To Get the Most Out of Your Mushrooms

Your gut is connected to digestion, immunity, mood, and even skin health. And while probiotics and mushroom powders often get the spotlight, it’s your everyday choices that really set the tone for your gut microbiome.

Start with your plate. A fiber-rich diet full of fruits, veggies, legumes, and whole grains feeds your beneficial gut bacteria. Meanwhile, fermented foods like kimchi, sauerkraut, and kefir help deliver live cultures that help maintain balance in your microbiome. Prebiotics like garlic, onions, and leeks can also act as fertilizer for those good bacteria.

Hydration keeps things moving (if you know what we mean), while regular movement, like walking or yoga, promotes digestion and lowers inflammation all around. Sleep and stress management are also so important. Chronic stress and erratic sleep can disrupt gut flora and increase intestinal permeability, which can cause inflammation all over the body.

Last but not least, make sure you don’t use too many antibiotics, NSAIDs, and artificial sweeteners, which can alter the diversity of your gut microbiome. Remember, gut health isn’t about one new supplement or one choice — it’s based on a lifestyle of good habits and consistency.

How Can You Tell if You Have Poor Gut Health?

Your gut has ways of letting you know when things aren’t going well. And, contrary to popular belief, it’s not always through your stomach.

Yes, bloating, constipation, diarrhea, and gas are the usual suspects. But gut dysfunction can also show up as brain fog, fatigue, mood swings, sleep issues, skin flare-ups (think eczema or acne), and even bad breath.

Frequent sugar cravings might be another sign that your gut microbiota is out of whack. The bad bacteria feed on refined carbs and send signals for more.

An imbalanced gut can also damage your immune system, leaving you more prone to colds, infections, or even autoimmune reactions. Food sensitivities can also creep in, and once-tolerated foods could suddenly cause discomfort or inflammation.

What About Digestive Disorders?

Ulcerative colitis (UC) and Crohn’s disease are two forms of inflammatory bowel disease (IBD), conditions marked by chronic inflammation of the gastrointestinal tract. UC affects the colon and rectum, while Crohn’s can target any part of the GI tract, often in patchy areas. Both can cause abdominal pain, bloody stools, fatigue, weight loss, and difficulty absorbing nutrients.

However, reishi has adaptogenic and anti-inflammatory properties that may support barrier function and reduce inflammation in the gut. Meanwhile, lion’s mane could support nerve regeneration in the enteric nervous system, which may help your food move at a normal pace during IBD flare-ups. Finally, chaga may help minimize oxidative stress to support the gut.

Frequently Asked Questions

How long until I notice gut improvements?

Gut improvements with mushroom supplements vary, but many people notice subtle changes within a few weeks. Increased regularity, less bloating, and more balanced digestion often appear gradually as the gut microbiome adjusts.

Can I take multiple mushroom extracts together?

Yes, combining mushroom extracts can actually increase gut and overall wellness benefits. Each mushroom offers unique compounds, from beta-glucans to antioxidants, which can all work together. Blends often provide more comprehensive support than a single extract. For instance, our Mushroom Coffee+ contains both lion’s mane and chaga mushrooms.

What’s the difference between fruiting body and mycelium supplements?

The fruiting body is the visible mushroom that contains high levels of bioactive compounds, like beta-glucans. Mycelium, the root-like network beneath the soil, also has beneficial compounds, but often in smaller amounts. Many experts prefer fruiting body supplements for their higher concentration of active ingredients.

Do I need to take my supplement every day?

Consistency is key for gut health. Taking your mushroom supplement daily is a great way to make sure your body continuously benefits from prebiotic fibers, immune modulation, and anti-inflammatory effects. Using it every now and then may provide some support, but steady intake can provide more noticeable and lasting improvements.

How can I remember to take my mushroom supplement every day?

One of the easiest ways to stay consistent is by building mushrooms into a daily ritual you already enjoy — like coffee. Our mushroom blends make this simple, since each cup blends gut-supportive mushrooms with your morning brew.

Instead of remembering a pill, you can get your daily Dose while sipping a drink you already love. Or, you can try some of our recipes to level up your morning ritual.

The Bottom Line

We’re not exaggerating when we say gut health is one of the keys to full-body health. Whether your issue is brain fog, skin breakouts, indigestion, stress, or poor sleep, it’s likely that you can trace it back to your gut. Luckily, addressing these issues isn’t too hard. Here’s a sample plan to follow.

Your 3-Step Gut Health Plan

Prioritize Diet : Incorporate fiber-rich whole foods, fermented options like sauerkraut or kimchi, and limit processed foods that can disrupt gut balance.
Support Sleep : Aim for seven to nine hours of restorative sleep to regulate the gut-brain axis and promote microbial balance.
Add Mushrooms : Use functional mushrooms daily (like putting them in your coffee, *wink* *wink*) to feed beneficial bacteria, soothe irritation, and strengthen gut defenses.

At Everyday Dose, we designed our nootropics stack to take advantage of this knowledge. We knew our formula shouldn’t just provide cognitive support — it should support the gut, too. That’s why we developed our full selection of mushroom blends with only five of the highest-quality ingredients out there. Shop all of our blends today and find one that works for you!

Sources:

The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health | PMC

The Gut-Skin Axis: Interaction of Gut Microbiome and Skin Diseases | Frontiers Research Topic

Mushroom, lion's mane | USDA

5 Reasons to Consider Chaga Mushrooms | American Association of Naturopathic Physicians

Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism | PMC

Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults | PubMed

Turkey tail mushroom (Trametes versicolor): an edible macrofungi with immense medicinal properties | ScienceDirect

Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Inhibits Candida Biofilms: A Metabolomic Approach | PubMed

Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia | PubMed

Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study | PMC

Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation | PMC