What Are the Long-Term Effects of Caffeine on the Brain?
Most of us aren’t reaching for that cup of coffee because we love bitter bean juice. We want the buzzing energy that it brings to help kick us out of bed. And this buzz is thanks to our favorite coffee compound: caffeine.
However, caffeine can have long-term effects on the brain, and not all of them are good. In fact, most of the long-term effects of high caffeine consumption are less than ideal. Read on to learn more about the effects of caffeine and how you can cut back on your consumption.
1. Supports Memory and Learning
Caffeine can support memory, focus, and attention over time. One study found that caffeine can actually help with long-term memory consolidation. Basically, it helps you file away information better.
Even better, some studies link moderate caffeine intake with long-term brain health and sharp thinking as you age. One theory about this benefit is that caffeine blocks adenosine, a neurotransmitter that helps promote sleep, which may in turn protect brain cells from damage.
So yes, your daily dose may taste good, but it might also keep you thinking fast for the next couple of decades.
2. Rewires the Brain
Did you know your coffee habit might literally change the shape of your brain? In one Swiss study, MRI scans showed that daily caffeine consumption led to a reduction in gray matter volume in the hippocampus, the part of the brain that’s all about memory and navigation.
Don’t worry, though — it wasn’t permanent. After about 10 days without caffeine, everything went back to normal.
Additionally, caffeine can also support something called brain entropy. Higher entropy just means your brain is firing on more cylinders, processing more information in a more flexible way. It’s like putting your brain into sport mode.
3. May Affect Mental Health
While caffeine can feel like a godsend during that 3 P.M. slump, too much can cause anxiety, especially if you’re already prone to it. Research shows that long-term caffeine use can trigger or worsen anxiety symptoms, even in people who are not otherwise at risk for anxiety. If you’ve ever had a panic attack after one too many cold brews, you know exactly what we’re talking about.
And in super rare cases, high doses of caffeine have been linked to psychosis. The kind that comes with delusions and hallucinations, the whole nine yards. This typically only happens with extreme overconsumption or underlying mental health conditions, but still... maybe don’t chase five energy drinks with an espresso shot.
4. May Disrupt Sleep
Caffeine doesn’t just help you stay awake — it actively blocks adenosine, the chemical your brain uses to tell the rest of your body that it’s bedtime. So when you down a late-afternoon latte, you’re silencing those signals, whether you mean to or not. This might be helpful when you need a jolt of energy for a meeting, but you’ll start to feel the consequences later in the evening.
Caffeine can reduce total sleep time, mess with REM sleep (AKA dream time), and delay your body’s natural clock. One study found that even consuming caffeine six hours before bed can affect your sleep quality. You might think you’re sleeping fine, but your brain could be suffering the consequences.
Plus, light, restless sleep means you wake up feeling like a zombie, even after eight hours. So if you’re wondering why you’re tired even after sleeping, that 4 P.M. cappuccino might be the culprit.
5. Causes Dependency in Some Cases
Some of us aren’t “enjoying” caffeine anymore. We’re depending on it like it’s a personality trait (you know who you are). That groggy, foggy, slightly ragey feeling you get when you skip your morning coffee is caffeine withdrawal.
Caffeine affects the central nervous system, and drinking it all the time changes how your brain responds to it. Over time, your body starts to rely on caffeine to feel “normal.” Skip it for a day or two, and your brain throws a tantrum: headaches, fatigue, irritability, and mood dips are all common withdrawal symptoms.
Caffeine withdrawal is even a clinically diagnosable condition. But don’t worry — you’re not doomed forever. Tapering your intake slowly can help reset your caffeine tolerance without the brain fog and crankiness.
How To Determine Your Caffeine Tolerance
Caffeine isn’t a one-size-fits-all situation. Some people can sip espresso after dinner and sleep like a baby. Others look at a green tea and suddenly their heart’s doing flips. So, how do you figure out your own caffeine tolerance? Start by paying attention.
It helps to keep a caffeine journal (yes, really). Track how much you consume, what time you have it, and how you feel afterward. Are you focused and energized? Or jittery and spiraling into a bad time?
Your genetics also play a role. Some people metabolize caffeine more slowly, so it lingers in the system longer, causing more side effects. If you’re genetically caffeine-sensitive, even small amounts can crank up anxiety, disrupt your sleep, or make you feel lightheaded. To figure out your own tolerance, you can always talk to family members to see what their experiences with caffeine are like.
It’s all about listening to your body. There’s no award for drinking the most coffee. If half a cup gets you through the day, that’s part of what makes you a rockstar. Own it.
What’s the Caffeine Sweet Spot?
Let’s bust a myth: Just because the “recommended” daily caffeine limit is around 400 mg, it doesn’t mean you should be throwing back four cups a day. For many people, that’s way too much. Everyone’s caffeine threshold is different, and finding your sweet spot is way more important than hitting an arbitrary number.
We’ve found that about 45 mg of caffeine per serving is a golden zone, in our experience. It’s enough to support alertness, encourage focus, and spark some energy, but it shouldn’t launch you into a full-body anxiety spiral or send your digestive system into chaos.
If you’re prone to jitters, anxiety, or sleep issues, sticking to lower doses might be your best move. There’s no shame in the low-caffeine game. It’s not about being the most caffeinated person in the room, it’s about feeling your best.
How Can You Cut Down on Caffeine?
If you’re already drinking way too much caffeine (and suffering from it), don’t panic. You don’t have to break up with it completely.
Caffeine actually has proven benefits like alertness, mood, and memory, so this isn’t about ghosting your coffee altogether — it’s about setting healthy boundaries. One great way to cut down without feeling deprived is by swapping one of your daily brews for something like our Mushroom Coffee+.
It gives you that rich, bold coffee flavor you love, but with only 45 mg of caffeine per serving, so you still get the benefits without the side effects. Plus, it’s packed with L-theanine to help smooth out caffeine’s side effects, lion’s mane mushroom to support focus, chaga mushroom for its antioxidants, and collagen protein to keep your hair, skin, and nails on point.
The Bottom Line
Caffeine isn’t your enemy, but it also shouldn’t be your boss. Understanding how it affects your brain, sleep, and mood can help you make smarter choices about how much and when to consume it.
Finding your personal sweet spot is the real win, not chasing the highest buzz. And if you want a feel-good, balanced option, our mushroom blends can help you experience the rush of a good cuppa without falling into the unpleasant side effects.
Sources:
https://pmc.ncbi.nlm.nih.gov/articles/PMC4115451/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3805807/
https://jaapl.org/content/early/2020/05/13/jaapl.003923-20
https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2024.1270246/full
https://www.bps.org.uk/research-digest/caffeine-causes-widespread-brain-entropy-and-thats-good-thing
https://www.nature.com/articles/s41598-024-61421-8
https://www.sciencedirect.com/science/article/abs/pii/S0002916524006713
